Substrates of muscle metabolism
نویسندگان
چکیده
Muscle is a major player in metabolism. It uses large amounts of glucose in the absorptive state and changes in muscle insulin-stimulated glucose uptake alter whole-body glucose disposal. Lipid substrates such as fatty acids or ketone bodies are preferentially used by muscle in certain physiological conditions. Muscle is also the main reservoir of amino acids and protein. The activity of many different plasma membrane transporters such as glucose carriers, carnitine, creatine or amino acid transporters maintain muscle metabolism by taking up or releasing substrates or metabolites across the cell surface. The goal of this review is the molecular characterization of muscle membrane transporter proteins and the analysis of their regulatory roles. Resum El múscul té un paper central en el metabolisme. Així, el múscul utilitza quantitats substancials de glucosa durant l’estat absortiu, i els canvis en la captació muscular de la glucosa provoquen alteracions en la utilització global de la glucosa per l’organisme sencer. El múscul constitueix també el principal reservori corporal d’aminoàcids i de proteïnes. A més, el metabolisme muscular és mantingut mitjantçant l’activitat de molts diferents transportadors localitzats a la membrana plasmàtica, com són els transportadors de glucosa, carnitina, creatina o aminoàcids; aquests transportadors capten o alliberen, a través de la membrana plasmàtica de la cèl·lula muscular, diferents substrats o metabòlits. L’objectiu d’aquesta revisió consisteix en la caracterització molecular de les principals proteïnes transportadores presents a la membrana plasmàtica de les cèl·lules musculars, així com l’anàlisi de les seves propietats reguladores.
منابع مشابه
Determining whether positively-charged channel-forming molecules of polyene antibiotic with aromatic groups affect muscle activity?
This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...
متن کاملDetermining whether positively-charged channel-forming molecules of polyene antibiotic with aromatic groups affect muscle activity?
This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...
متن کاملNutrient regulation of skeletal muscle protein metabolism in animals. The involvement of hormones and substrates.
متن کامل
Role of plasma membrane transporters in muscle metabolism.
Muscle plays a major role in metabolism. Thus it is a major glucose-utilizing tissue in the absorptive state, and changes in muscle insulin-stimulated glucose uptake alter whole-body glucose disposal. In some conditions, muscle preferentially uses lipid substrates, such as fatty acids or ketone bodies. Furthermore, muscle is the main reservoir of amino acids and protein. The activity of many di...
متن کاملEffects of natural polymer (Poly-β-hydroxybutyrate) and its degrading bacteria on lipid metabolism and digestive tract pH in Siberian Sturgeon Acipenser baerii Brandt, 1869 fingerlings
Five hundred and ninety two Siberian sturgeon (A. baerii) fingerlings (average weight, 11.1±0.9 g) were randomly distributed in 16 tanks (150 L) at a density of 35 fish per tank and fed different treatments (Control, degrading bacteria, 2% PHB, degrading bacteria + 2%PHB) for 60 days. At the end of the experiment, the results indicated that the fish fed PHB or bacteria treatments had low midgut...
متن کامل